STAT3, Cten, and lung cancer: Simultaneous excitement and caution
نویسندگان
چکیده
منابع مشابه
Stat3 and Gap Junctions in Normal and Lung Cancer Cells
Gap junctions are channels linking the interiors of neighboring cells. A reduction in gap junctional intercellular communication (GJIC) correlates with high cell proliferation, while oncogene products such as Src suppress GJIC, through the Ras/Raf/Erk and other effector pathways. High Src activity was found to correlate with high levels of the Src effector, Signal Transducer and Activator of Tr...
متن کاملExpression and clinical significance of STAT3, P-STAT3, and VEGF-C in small cell lung cancer.
OBJECTIVE To determine STAT3, P-STAT3, and VEGF-C expression levels in small cell lung cancers (SCLCs), and discuss their role and clinical significance in SCLC development. METHOD Immunohistochemical methods were applied to 128 cases of SCLC and 40 cases of adjacent normal tissue. RESULTS The expression levels of STAT3, P-STAT3, and VEGF-C were higher in SCLC than in normal tissue (P<0.05)...
متن کاملConstitutively active Stat3 enhances neu-mediated migration and metastasis in mammary tumors via upregulation of Cten.
The transcription factor signal transducer and activator of transcription 3 (STAT3) is constitutively activated in tumors of different origin, but the molecular bases for STAT3 requirement are only partly understood. To evaluate the contribution of enhanced Stat3 activation in a controlled model system, we generated knock-in mice wherein a mutant constitutively active Stat3C allele replaces the...
متن کاملPulmonary tuberculosis and lung cancer: simultaneous and sequential occurrence*
OBJECTIVE Lung cancer (LC) is the leading cause of cancer-related death and represents a major public health problem worldwide. Another major cause of morbidity and mortality, especially in developing countries, is tuberculosis. The simultaneous or sequential occurrence of pulmonary tuberculosis and LC in the same patient has been reported in various case series and case-control studies. The ob...
متن کاملAtorvastatin Sensitizes Breast and Lung Cancer Cells to Ionizing Radiation
Tumour cells may be resistant to radiotherapy that results in unsuccessful cancer treatment in patients. The aim of this study was to evaluate the sensitizing effect of atorvastatin (ATV) on breast cancer (MDA-MB-231) and non-small cell lung cancer (A-549) cells following exposure to ionizing radiation (IR). These cells were treated with ATV and exposed to X-ray at dose 4 Gy. The radiosensitizi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 2015
ISSN: 0022-5223
DOI: 10.1016/j.jtcvs.2014.09.053